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The copper content of GHK-Cu formulations has been a theoretical safety consideration, given that excessive copper can be toxic - however, the amounts used in cosmetic and research applications are extremely small, the copper is tightly chelated by the peptide (reducing free copper availability), and topical absorption of copper from these products appears minimal and well below levels that would cause systemic copper accumulation or toxicity

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*Aneja, A

In short, clinical data highlights the high prevalence of NPS and their worsening over the progression of AD ( Pathologies of NPS in AD patients Human macrostructure (CT, MRI) and microstructure imaging (such as diffusion MRI), as well as functional imaging (fMRI), has been applied to investigate the brain changes related to NPS in AD