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Serious adverse events remain rare with both compounds when prescribed and monitored appropriately

Retatrutide is as safe as other similar drugs, with common side effects like stomach problems

Results are presented as the mediated proportionthat is, the indirect/weight-loss-dependent effect divided by the total effect, with corresponding CIs

Module 4 is the prescribing core: microdosing timeline, starting doses and titration strategy, body composition monitoring with InBody, key metabolic labs (FSI, HOMA-IR, ApoB, hs-CRP), when to increase, hold, or taper, and side effect management

Rinse cautiously with water for several minutes

doi:10.3945/jn.110.122697 Institute of Medicine