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Hepatology 69 , hep.30583 (2019)

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Too much estrogen being metabolized through CYP1B1 into 4-OHE1(E2) and the estrogen quinones can potentially be bad if your body has slower phase II (COMT, GSTP1, GSTM1, NQO1) enzymes.[ref][ref] The connection between smoking and estrogen-related cancers: Smoking significantly increases the risk of breast cancer and prostate cancer

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Persistently elevated IGF-1 has been associated with increased risk of certain cancers in epidemiological studies (Renehan et al., Lancet 2004)