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Figure 1 A metabolite set enrichment analysis made from the 31 metabolites significantly modulated by MTX confirmed the major impact of the drug on glycine and serine metabolism, the urea cycle, alanine metabolism, and arginine and proline metabolism ( Figure 1B )

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[DOI] [PMC free article] [PubMed] [Google Scholar] 188.Phalen T.J., Weirather K., Deming P.B., Anathy V., Howe A.K., van der Vliet A., Jonsson T.J., Poole L.B., Heintz N.H