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It is highly cardioselective as it is predominantly deposited in the heart relative to other tissues and blood (Tang et al., 1995a

143:e815

However, addition of the insulin receptor antagonist S961 had no influence on the effect of glucagon on somatostatin secretion

This broader mechanism is believed to enhance its effects on insulin sensitivity and appetite signaling in research models

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Someone who loses 50 pounds in five months may experience more pronounced adaptation than someone who loses the same amount over twelve months