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A-42 aggregates and combines to Ca 2+ channels and AMPA (-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors, to which the neurotransmitter glutamate binds, so A is the most neurotoxic form (31)

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In high-intensity exercise, this metabolic shift is hypothesized to increase energetic efficiency, reduce lactate accumulation, delay fatigue, and accelerate post-exercise recovery, which helps explain its attraction in elite sport ( Also, persistent uncertainty regarding long-term safety, limited high-quality human data in athletes, and its status as a banned substance continue to raise ethical and regulatory concerns ( Human physical performance: mechanistic rationale vs

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