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In the reference formulation discussed here, yes

Glimepiride (n=135) was administered at 1mg initially, and then titrated up to 2, 4 or 8 mg (mean last dose 4 mg) until the therapeutic goal of self-monitored fasting blood glucose 65 years (n=42) was performed in a study using a dosing regimen of 6 mg daily

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Animals were individually housed in stainless steel cages for the duration of the study under a controlled environment that was set to maintain a temperature of 1824 C, relative humidity of 3070%, and a 7:00 AM7:00 PM light/dark cycle