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MSU crystals activate the p300/CBP acetyltransferase, inducing H3K27ac enrichment at enhancer regions of inflammatory genes (e.g., CXCL8 and PTGS2 ) within macrophages, thereby prolonging inflammatory responses (Punzi et al., 2025)

In: Feingold KR, Ahmed SF, Anawalt B, et al ., eds

Maghsoudi H, Sheikhnia F, Sitarek P, Hajmalek N, Hassani S, Rashidi V, Khodagholi S, Mir SM, Malekinejad F, Kheradmand F, Ghorbanpour M, Ghasemzadeh N, Kowalczyk T

[PMC free article: PMC4446235] [PubMed: 25754159] (Among 899 cases of drug induced liver injury enrolled in a prospective database between 2004 and 2012, HDS were implicated in 145 [16%] of which 5 were attributed to Hydroxycut [Navarro

272 In addition, other mechanisms may be responsible for this difference in enzyme activity

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