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Tirzepatide generally produces greater average weight loss in clinical trials, with the SURMOUNT-1 trial showing up to 22.5% body weight reduction at the highest dose compared to semaglutide roughly 15-17% in comparable trials

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In addition, the activation of GABA B receptors depresses the GABA A receptor-mediated Ca 2+ increase and therefore the GABA B pathway is likely supervising the entry of Ca 2+ [6]

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