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On one hand, having multiple targets can produce synergistic efficacy in complex diseases
Harazin A, Bocsik A, Barna L, Kincses A, Vradi J, Fenyvesi F, et al
Wohlfart et al., 2008
Finally, long-term safety follow-up (12 months) is essential to assess risks of chronic Nrf2 activation (e.g., cancer progression) or antioxidant interference with physiological ROS signaling, highlighted by the bardoxolone methyl experience in diabetic kidney disease (Nangaku et al., 2020)
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GSH is a promising and clinically feasible drug that promotes fat graft survival by inhibiting ferroptosis via the SLC7A11/GPX4 axis
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