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In the inflammatory depression models, a mild to moderate chronic consumption of caffeine reversed the LPS-induced depressive behaviors in the OFT, in the FST, and the TST [32,33,34, 36]

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Moreover, comprehensive coverage of all target regions was confirmed covered, through visual inspection using the Integrative Genomics Viewer (IGV) tool [42] (Figure S2)

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Overview of main clinical studies for MASLD/MASH with GLP-1 receptor agonists and dual or triple agonists targeting glucagon/GIP/GLP-1 receptors Liraglutide Liraglutide, a once-daily GLP-1 receptor agonist with authorized indications for type 2 diabetes and obesity, was evaluated in the LEAN trial (NCT01237119), a phase 2 randomized controlled study enrolling 52 adults with biopsy-proven MASH [22]