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Treatment of p47phox knockout animals with DOCA-salt markedly reduced levels of oxidative stress and abolished superoxide reducing effects of NOS inhibition compatible with a prevention of eNOS uncoupling

It is beneficial in many ways

Microdosing is an off-label strategy, and all patients are fully consented

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Its well-known adverse events, e.g., interstitial pulmonary fibrosis, seizures, liver veno-occlusive disease, or sinusoidal obstruction syndrome [96] seem to be caused by glutathionyl-tetrahydrothiophene, a metabolite that derives from the irreversible GSH conjugation [97,98]

doi:10.1016/j.euf.2018.04.013