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Duan MC, Zhong XN, Liu GN, Wei JR

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The safety and the convenience of use (once-daily or twice-daily doses in combination with metformin) of the DPP-4 inhibitors have made them one of the most commonly used drug options, particularly in the early stages of the disease, in patients with renal failure, and in elderly subjects.39 Glucagon-like peptide-1 (GLP-1) receptor agonists These drugs bind to the GLP-1 receptors, inducing a decrease in glucagon secretion and an increase in insulin secretion, both in a glycemia dependent manner

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"Semaglutide vs Tirzepatide for Weight Loss in Adults with Overweight or Obesity," JAMA Internal Medicine