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In the brain sections of epileptic rats, acute epileptic activity promoted ATP production, whereas chronic epileptic activity decreased ATP production capacity by 25% to 40% (70)

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Wang J, Seebacher N, Shi H, Kan Q, Duan Z (2017) Novel strategies to prevent the development of multidrug resistance (MDR) in cancer

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And almost everyone with ankylosing spondylitis experiences flares, periods of time when pain gets worse, followed by remission, which is when symptoms subside