developed supramolecular prodrug nanoassemblies (SPNA) for reactive nitrogen species (RNS)-enhanced chemotherapy (Figure 3D) (Figures 3E, F), thereby generating highly toxic peroxynitrite anion (ONOO )
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This epigenetic alteration can persist long after alcohol consumption has ceased, leading to long-term deficits in BDNF levels and associated depressive symptoms
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