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Both receptors share a typical structure consisting of a carboxy-terminal ligand-binding domain, a DNA-binding site located in the center region, and an amino-terminal domain

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J Cell Biol 170:11011111 Sarkar S, Davies JE, Huang Z, Tunnacliffe A, Rubinsztein DC (2007) Trehalose, a Novel mTOR-Independent Autophagy Enhancer, Accelerates the Clearance of Mutant Huntingtin and -Synuclein