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Whether those effects run through GHIGF-1 signaling, direct GHSR-1a activation in cardiomyocytes, or some combination remains an active question

They are not mutually exclusive a researcher can run 5-on/2-off within an 812 week block and still take the 4-week macro-break afterward

Importantly, no glycemic differences were detected among the treated groups (QCN-GP, QCN-HS-GP, F-GP), demonstrating that all diabetic cohorts shared a comparable baseline metabolic dysfunction before topical therapy

Oncotarget 6:2200622027 Esworthy RS, Mann JR, Sam M, Chu FF (2000) Low glutathione peroxidase activity in Gpx1 knockout mice protects jejunum crypts from gamma-irradiation damage