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In a Cochrane review investigated AOX supplementation protocols for male subfertility, focusing on active substances including carnitines, coenzyme Q10, selenium, zinc, vitamins C and E, and carotenoids

Mechanistic interpretations in these studies typically rely on indirect evidence, such as changes in protein markers (e.g., Bax/Bcl-2 ratio, caspase activity), while direct causal validationthrough gene silencing, overexpression, or target binding assaysis rare (Xu G

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[DOI] [PubMed] [Google Scholar] 179.Singla-Pareek S.L., Kaur C., Kumar B., Pareek A., Sopory S.K