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[DOI] [PubMed] [Google Scholar] 32.Gainza-Cirauqui ML, Nieminen MT, Novak Frazer L, Aguirre-Urizar JM, Moragues MD, Rautemaa R

3.2.3 Impact of metformin on pregnant patients with polycystic ovary syndrome and preeclampsia Research has shown that metformin can inhibit the placental secretion of soluble fms-like tyrosine kinase 1 and promote arterial dilation, which suggests metformin may be a potential preventive and therapeutic agent for preeclampsia

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With regard to mitochondrial autophagy, the absence of Park2an E3 ubiquitin ligase that plays a critical role in this processleads to mild cardiac abnormalities and persistent defects in mitochondrial metabolic function

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