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Doctors often recommend these medications alongside lifestyle changes like diet and exercise

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| Province | Form Name | Who Submits | Typical Criteria | Renewal Period | | --- | --- | --- | --- | --- | | Ontario | Limited Use (LU) Code 474 | Prescribing physician enters LU code | Type 2 diabetes + inadequate glycemic control despite metformin | Annual | | British Columbia | Special Authority Request | Physician submits to PharmaCare | A1C above 7% despite optimized metformin dose (or metformin contraindicated) | Indefinite | | Alberta | Special Authorization | Physician submits to Alberta Blue Cross | Type 2 diabetes + tried first-line therapy | 2 years | | Quebec | Medicament d'exception | Physician completes the form | Type 2 diabetes + failure of at least one oral antidiabetic agent | Annual | | Saskatchewan | Exception Drug Status (EDS) | Physician submits EDS request | Type 2 diabetes + A1C above 7% on other agents | 12 months | | Manitoba | Special Authorization | Physician submits to Manitoba Pharmacare | Type 2 diabetes + inadequate control | Indefinite | Most applications take 2 to 4 weeks for approval

Jpn J Pharmacol 2000 Jun