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SFN displays an immunosuppressive effect on ex vivo T-cells from RA patients and provokes ROS production in whole blood lymphocytes Low ROS levels in RA patient-derived T-cells were linked to biased differentiation of T-cells into IFN- and IL-17-producing inflammatory cells ( H 17 related genes

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Studies show that collagen-derived peptides can stimulate fibroblasts the cells responsible for producing collagen to increase their activity