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The similar cardioprotection evoked by 4-ClDzp in the two distinct models of oxidative stress (diamide and ischemia/reperfusion) suggests that this compound is targeting a common pathway activated during ROS bursts, namely the mitochondrial ROS-induced ROS release mechanism

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Sidhu H, Allison MJ, Chow JM, Clark A, Peck AB

doi: 10.3389/fnut.2022.988529 152 BretinAZouJSan YeohBNgoVLWinerSWinerDAet al

Afterward, the supernatant was collected