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In vitro, Exendin-4 (0-20nM) incubated HUVEC cells for 15 minutes, which induced a dose-dependent increase in intracellular cAMP concentration, and Exendin-4 (20nM) increased the production of NO in HUVEC cells and increased p-eNOS and GTPCH1 levels [4]

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Exenatide Exendin-4 is a hormone extracted from the venom of the lizard Heloderma suspectum, exhibiting biological effects similar to human GLP-1

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This outcome aligns with the findings of Hassan et al

For tirzepatide users, constipation management , diarrhea duration , and fatigue follow similar patterns