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Drp1 is activated by various cellular stimuli, translocates from the cytoplasm to the outer mitochondrial membrane, interacts with Fis1, and induces mitochondrial fission [82]
The clinical consequences could range from local inflammation or rash through to serious health issues, such as systemic hypersensitivity, including anaphylaxis, or antibody formation
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Pickett and Lu, 1989
Proposed mechanisms include upregulation of growth factor receptors, stimulation of fibroblast migration and collagen synthesis, and promotion of angiogenesis at injury sites
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