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Alternatives might include switching to a different GLP-1 medication (some patients tolerate one better than another despite similar mechanisms), reducing the maintenance dose to a level that produces fewer GI effects while still providing benefit, or transitioning to tirzepatide or another agent in the class
Rare but serious side effects Both tirzepatide and semaglutide can cause more serious side effects, though these are rare
The endocrine role of brown adipose tissue: an update on actors and actions
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