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This has not been without controversy with many linking the rise in obesity with the industrialised food system and increase in consumption of ultra-processed food (Poti, Bragga, Qin)
These medications work through entirely different mechanisms in the body and do not interfere with each other's pharmacological pathways
doi: 10.1210/endo.137.6.8641190
When fermented by gut bacteria, they produce metabolites that directly stimulate GLP-1 secretion
Moreover, sitagliptin, linagliptin, saxagliptin, and alogliptin could induce joint pain [20, 21]