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Safety, tolerability, pharmacokinetics, and pharmacodynamics of concomitant administration of multiple doses of cagrilintide with semaglutide 24 mg for weight management: a randomised, controlled, phase 1b trial

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Real-World Evidence: A retrospective cohort study using electronic health record data found that tirzepatide was associated with a mean weight loss of 6.6 kg compared to 3.1 kg for semaglutide over a 6-month follow-up period

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White, G

By binding to these receptors, GLP-1 enhances insulin secretion from pancreatic -cells and suppresses glucagon secretion in a glucose-dependent manner, slows gastric emptying, and regulates appetite by increasing satiety and promoting a sense of fullness through its action on the hypothalamus [27, 28, 31,32,33]