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No lethal dose was reached in preclinical toxicology studies, and no significant adverse effects have been reported in published research

Mund RA, Frishman WH (2013) Brown adipose tissue thermogenesis: 3-adrenoreceptors as a potential target for the treatment of obesity in humans

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Fourth, an important issue that is often raised is whether any GLP-1RAs can indeed penetrate the bloodbrain barrier and therefore express any neurobiological activity in the CNS, which would result in cognitive or behavioral changes

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