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Limitations of ferroptosis-targeted agents A growing number of evidence supports the role of ferroptosis in the initiation and progression of various metabolic diseases such as T2DM

FIGURE 4 3.4 Effect of glycitin on oxidative stress markers The analysis of oxidative stress markers demonstrated that the concentrations of MDA were significantly higher in the CN group in comparison with the VC group (P = 0.0043, Figure 5A)

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Although we identified a likely link between the Na + and carnitine sites, further structural and functional investigations will be necessary to define the precise details of how coupling between the Na + binding and structural change at the carnitine-binding site is mediated