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Excessive production of RAGE on brain microvascular endothelial cells increases A transport into the brain tissue and decreases its removal, leading to the accumulation of A in the brain tissue, which in turn triggers a series of neurodegenerative pathological changes, such as the formation of amyloid plaques, the formation of neurofibrillary tangles, and the loss of neurons (23)

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Patients taking oral semaglutide often experience improvements in key cardiovascular risk factors, including reductions in systolic blood pressure, lower cholesterol levels, and better blood sugar control

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