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Rybelsus should be used with caution in patients with severe kidney dysfunction Semaglutide should not be used in individuals with a personal or family history of Medullary Thyroid Carcinoma (MTC) or in those with Multiple Endocrine Neoplasia syndrome type 2

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A plateau forms when the lower intake meets the lower energy expenditure of a smaller body

Furthermore, comparisons were based on a network of studies reporting on all relevant OMMs in the population of interest, which is a wider scope compared with previous head-to-head trials, indirect treatment comparisons and cohort studies [23, 24] but a narrower scope compared with previous NMAs [21, 22]