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Volunteers with type 2 diabetes were recruited from the diabetes specialty clinics at the Diabetes Association of Jamaica and the University Hospital of the West Indies, Kingston, Jamaica

doi: 10.23736/s0391-1977.20.03268-x 100 RostamiRNourooz-ZadehSMohammadiAKhalkhaliHRFernsGNourooz-ZadehJ

In all studies except one of inositol [39], the investigators assessed mitochondrial modulator add-on to conventional treatment, such as pharmacotherapy (in most studies, serotonin reuptake inhibitors) or psychotherapy

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Given the pathological role of oxidative stress generation in MCP-1 induction and apoptotic cell death in tubular cells, hyperglycemia-elicited ROS generation might be a therapeutic target of tofogliflozin (157, 158)

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