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Cartilage has limited circulation and lacks direct nerve connections, so nutrients and repair signals move slowly

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Moreover, chronic stress exposure triggers systemic inflammatory activation through upregulation of pro-inflammatory cytokine cascades (Ravi et al., 2021)

However, you should never use glutathione in a nebulizer or inhale it if you have asthma, as this can trigger a bronchospasm

If, however, you're designing a study specifically to test the local gut effects of peptides, then an oral formulation might be your test article, but you'd be doing so with the full understanding of its limitations

doi: 10.1111/febs.16465 33 LinC-YChenWLHuangYCLimCLYangCH