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Of note, all AE outcomes were severe, including dulaglutide: ketoacidosis (n = 58), marasmus (n = 17), hyperglycaemic hyperosmolar nonketotic syndrome (n = 12), diabetic ketosis (n = 4)

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Yet our liver transcriptomic results indicate that semaglutide may enhance thermogenesis and alter the circadian rhythm of malnourished mice, preventing energy investment in linear growth, anabolism and fat storage