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This mechanism is the same reason tirzepatide can slow gastric emptying and reduce appetiteit's part of how the medication reshapes your body's hunger and digestion signals

Sato T, Vries RG, Snippert HJ, van de Wetering M, Barker N, Stange DE, van Es JH, Abo A, Kujala P, Peters PJ, Clevers H (2009) Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

It contains, from the outside to the appendix lumen, the same components as the colon wall: serosa, subserosa, external muscular tunica, submucosa, a layer containing lymph nodes, an internal muscular layer with diffuse lymphatic tissue, mucosa, lamina propria, and epithelium

Riddle MC, Forst T, Aronson R, Sauque-Reyna L, Souhami E, Silvestre L, et al

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