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These are promising compounds with genuine mechanistic rationale, not proven therapeutics

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In general, the A1C lowering capacity is greatest for metformin and sulfonylureas (average 12%), next greatest for GLP-1 agonists and thiazolidinediones (average 11.5%), and least for meglitinides, dipeptidyl peptidase 4 (DPP-4) inhibitors, alpha-glucosidase inhibitors (AGIs), and colesevelam (average 0.51%)

Though they were just a bit slower, no more than 90 minutes passed from the time we sent our email inquiry to the moment we received a response

Patients who entered the cohort with a prescription for sulfonylureas and later switched to or added the incretin-based drug were considered as exposed to sulfonylureas from cohort entry to the date of filling the prescription for the incretin-based drug