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Signs of vitamin B6 deficiency include dermatitis (skin inflammation), glossitis (a sore tongue), depression, confusion and convulsions

Importantly, due to the possible occurrence of severe hypotension, combined therapy or prophylaxis with nifedipine and PDE5 inhibitors should be avoided

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If neurological symptoms worsen or fail to improve after four to six weeks of appropriate treatment , further investigation is necessary to exclude alternative diagnoses or complications

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No statistically significant differences were noted between groups regarding serum levels of testosterone, FSH, LH, and prolactin at baseline