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Moreover, insulin-like growth factor binding protein related proteins (IGFBPrPs) have been recently characterised, which aid the metabolic effects of the hormone but their role remains unclear [96, 97]

Seminars in cell & developmental biology 2012

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In this frame, lipids are in the list of molecules required by proliferating cells being components of cell membranes

It is estimated to represent 1-2% of all oral malignancies and accounts for about 0,1-8% of all melanomas.[6,7,15] Mean age of onset is 55-60,[6,7] however there have been reports of onset in prepubertal children.[16] Unlike cutaneous melanoma, oral melanoma is very frequent in Japan, Uganda and India