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In summary, long-acting GLP-1R agonists primarily reach the circumventricular organs of the hindbrain and food-intake controlling centers of the hypothalamus

One theoretical concern: could glutathione mitigate tirzepatide's GI side effects by reducing oxidative stress in the gut lining

For irritable bowel syndrome, multi-strain formulations containing Bifidobacterium and Lactobacillus species show the most promise

Steroid-sparing treatments, including immunosuppressive agents and biologics such as hydroxychloroquine, can reduce dependence on corticosteroids and limit their associated damage (109)

Mitidieri E, Cirino G, et al

But fortunately, patients can also include various natural remedies to their treatment plans