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In order to maintain low levels of reactive oxygen species (ROS), ascorbate peroxidase (APX) and GPX convert hydrogen peroxide to water in the ascorbate (AsA)-glutathione (GSH) cycle and oxidized glutathione (GSSG)-GSH cycle, respectively [8, 9]

Patients who benefit from thyroid replacement therapy at our practice include those diagnosed with primary hypothyroidism, which can result from autoimmune conditions like Hashimotos thyroiditis, surgical removal of the thyroid (thyroidectomy), or damage following radiation treatments for cancers of the head or neck

GR activity was measured according to Halliwell & Foyer 55 based on the rate of decrease in the absorbance of NADPH at 340 nm

Thus, targeting iron metabolism and ferroptosis may be a novel method to slow the progression of epilepsy

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