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doi:10.1016/s0165-1781(02)00262-7 Kahn RS, Westenberg HG, Verhoeven WM, Gispen-de Wied CC, Kamerbeek WD

But it introduces legitimate doubt about the additive benefit hypothesis and suggests that once incretin-based appetite suppression is maximized, additional norepinephrine-based suppression may have diminishing returns

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