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Caution applies for individuals with cardiovascular conditions, though topical application minimizes systemic exposure

However, the amount is extremely small and is not considered harmful

The bound copper is biologically active GHK-Cus signaling and regenerative effects are dependent on the copper moiety, not just the peptide

PMCID: PMC8706217

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Glycine is also a precursor for several critical biomolecules: it contributes to the synthesis of creatine (essential for muscle-energy storage), porphyrins such as heme, and purines, and it conjugates with bile acids to form bile salts