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Vitamin B12, cyanocobalamin

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Psychiatry 44 OchiaiT.SanoT.NagayamaT.KubotaN.KadowakiT.WakabayashiT.et al (2021)

Three hundred sixty-six pregnant women in India received 50 mcg of oral vitamin B 12 or placebo capsules once daily beginning during their first trimester of pregnancy and continuing until 6 weeks postpartum

Distinct from the previously designed -ketoamides, the P2P3 amide bond is replaced with a pyridone ring, which increases the half-life in plasma

In these studies, the average age of the enrolled subjects was 6065 years, which corresponds to the mean age of onset of PD, although the incidence of PD increases with age (12% over 65 years old and more than 5% over 80 years old)