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The top five precursor ions were subsequently fragmented, in a data-dependent manner, using the higher energy collisional dissociation cell set to 30% normalized collision energy in MS2 at a resolution power of 17,500

FERM subdomain 2 is bisected with a pleckstrin homology (PH) domain that is potentially involved in membrane binding and FERM subdomain 3 binds the membrane-distil NXXY motif on the -subunit of 1, 2 and 3 integrins

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Mechanistic linking of conserved aggresome biology with neuronal aggregate extrusion suggests alternative aggregate clearance options for mammalian aggresomes, and invites new considerations for therapeutic design