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- Slower Absorption: Oral supplements go through the digestive system, which means absorption can vary considerably
In that case, you can expect B vitamin levels to be suboptimal
High oral bioavailability Caco-2 cell assays showed excellent passive and active membrane transport with no detectable efflux (Neelakantan et al., 2018)
This is especially important if you have a high homocysteine level over 9 or have been tested to have low B12 or folate levels
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