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Doseresponse studies in healthy volunteers receiving graded intravenous GLP-1 infusions have demonstrated a linear correlation between systemic drug concentrations and the prolongation of the lag phase of solid gastric emptying [4]

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Adiponectin KO (Adipoq / ) (B6;129-Adipoqtm1Chan/J), UCP1 KO (UCP1 / ) (B6.129- Ucp1 tm1Kz /J) mice and their respective wild type controls were purchased from the Jackson Laboratory