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K + channels, including delayed rectifier K + channels and inwardly rectifying K + channels, contribute to repolarization and recovery, regulating firing timing and patterns (Tanaka et al., 2003)

however, most gastrointestinal events are of mild to moderate severity, transient and do not require permanent discontinuation of treatment (179,180)

Gastrointestinal side effects can indirectly affect hydration, but the direct UTI risk is equivalent to placebo

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