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Supplementary information Chemical structures of PHIs

The presence of glutathione inside human cells does not prove that a particular externally supplied formulation reaches the target tissue, remains chemically stable or produces a clinically meaningful outcome

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Some research suggests that it may have health benefits that include supporting digestion and heart health, among others

reported that PMX53, a C5a receptor 1 (C5aR-1) antagonist, mitigated hepatic IRI through inhibiting pro-inflammatory cytokine release and neutrophil/macrophage infiltration and platelet aggregation (Kusakabe et al., 2020), suggesting the crosstalk between coagulation and complement system