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The suppression of PGC-1 due to a deficit of endothelial nitric oxide synthase can lead to drastic decreases in activities of mitochondrial antioxidant enzymes ( Mitochondrial Dynamics Mitochondria are dynamic organelles that constantly change their morphology, size, and quantity through fission and fusion in response to cellular signals to meet metabolic demands ( Dynamin-related protein 1 (Drp1) is a protein responsible for the fission of the mitochondrial outer membrane

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