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GPR41 is expressed in autonomic and sensory ganglia, as well as in the vascular endothelium of both mice and humans (Nohr et al., 2015), modulating vascular tone in response to hypotensive signals from SCFAs (Natarajan et al., 2016)

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Over recent years, multiple studies have indicated that the use of glucagon-like peptide 1 (GLP-1) can cause an increased risk of gallbladder disease

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